Postdoctoral Fellow, Laboratory of Dr. Channing J. Der
Lineberger Comprehensive Cancer Center
University of North Carolina – Chapel Hill
Jennifer E. Klomp (Jenny) earned her B.S. in Biology with a minor in Chemistry from Grand Valley State University, M.S. in Microbiology from Central Michigan University, and Ph.D. in Cellular and Molecular Pharmacology from the University of Illinois in Chicago. Jenny is currently a postdoctoral fellow in the laboratory of Dr. Channing J. Der in the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill, where her research has been supported by T32 and F32 fellowships from the National Cancer Institute, and a fellowship from the American Cancer Society. Her work focuses on targeting kinases downstream of oncogenic KRAS, specifically in pancreatic cancer (PDAC). In this realm she has focused primarily on combined inhibition of ERK-MAPK and the DNA damage repair/cell cycle check-point kinase CHK1. Additionally, Jenny is evaluating the contribution of ERK1 versus ERK2 to the driver functions of oncogenic KRAS in PDAC. Jenny focuses on using physiologically relevant cancer cell lines and patient derived organoids, in combination with genomics, CRISPR-Cas9 loss-of-function screens, and biosensors, as well as protein engineering techniques. Her immediate goals are to interrogate the interplay between ERK1/2 MAPKs and DNA repair mechanisms and to identify the mechanistic basis of sensitivity and resistance to these inhibitor combinations. In the longer term, she hopes to translate her findings to improved treatment for PDAC patients.