Timothy A. Chan, M.D., Ph.D.

Member and Professor
Human Oncology and Pathogenesis Program
Memorial Sloan Kettering Cancer Center

Timothy A. Chan is a cancer geneticist and physician scientist with an interest in immunogenomics and immunotherapy.  He is the PaineWebber Chair in Cancer Genetics at the Memorial Sloan Kettering Cancer Center (MSKCC). He is a member/professor in the Human Oncology and Pathogenesis Program at MSKCC and Director of the Immunogenomics and Precision Oncology Platform (IPOP), a program focused on precision immuno-oncology. Dr. Chan obtained an M.D. and Ph.D. in genetics from the Johns Hopkins School of Medicine.  He went on to complete a residency in radiation oncology and a post-doctoral fellowship in epigenetics.  His main interests are utilizing cancer genomics, functional genomics, and statistical genetics to dissect the molecular determinants of tumor aggressiveness and response to cancer therapies.  He led the team that first described mutational burden as a determinant of clinical benefit to immunotherapy and showed that mutational landscapes help determine response to immune checkpoint blockade. His lab is developing pioneering approaches to examine neoantigens and the genomic foundations of response to cancer immunotherapy. 

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