Chairman, Department of Pediatric Oncology, Dana-Farber Cancer Institute
David G. Nathan Professor of Pediatrics, Harvard Medical School
Dr. Scott A. Armstrong is Chairman of the Department of Pediatric Oncology at Dana-Farber Cancer Institute, and the David G. Nathan Professor of Pediatrics at Harvard Medical School. Dr. Armstrong received his M.D. and Ph.D. from the University of Texas Southwestern Medical School in Dallas, Texas. Dr. Armstrong’s studies have led to several findings that point to promising new therapies. The major focus of his career has been on delineating the biology of childhood cancers and the development of new therapeutic approaches for children with cancer. He has developed a large research program that has focused on the mechanisms of leukemia development and the relationship between leukemia and normal hematopoietic stem cells. His lab has made fundamental contributions to the understanding of how leukemia arises from different cells in the hematopoietic system. Through this work, he has shown that myeloid leukemia stem cells are often most similar to committed myeloid progenitors that inappropriately express stem cell programs; a concept that has now been replicated in multiple cancers. He has also developed an interest in the mechanisms by which chromatin modifications control leukemogenic gene expression and has used this understanding to develop small molecule approaches that he continues to pursue. This work has led to the development of clinical trials that are being assessed in adults and children with cancer.